Journal
NATURE
Volume 482, Issue 7385, Pages 339-346Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10887
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Funding
- NIEHS NIH HHS [R01 ES020260] Funding Source: Medline
- NIGMS NIH HHS [P01 GM099117] Funding Source: Medline
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It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.
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