Journal
NATURE
Volume 481, Issue 7381, Pages 306-313Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10762
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Funding
- Leukaemia & Lymphoma Research UK
- Kay Kendall Leukaemia Fund
- American Cancer Society [117209-RSG-09-163-01-CNE]
- NIH [P01 CA91955, U54 CA143803, R01 CA149566, R01 CA140657]
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Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.
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