Journal
NATURE
Volume 481, Issue 7381, Pages 314-320Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10763
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Funding
- National Institutes of Health
- Canadian Diabetes Association
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The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
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