Journal
NATURE
Volume 488, Issue 7411, Pages 320-328Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11478
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Funding
- Joint BioEnergy Institute
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- Synthetic Biology Engineering Research Center
- National Science Foundation [0540879]
- Div Of Engineering Education and Centers
- Directorate For Engineering [0540879] Funding Source: National Science Foundation
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Advanced biofuels produced by microorganisms have similar properties to petroleum-based fuels, and can 'drop in' to the existing transportation infrastructure. However, producing these biofuels in yields high enough to be useful requires the engineering of the microorganism's metabolism. Such engineering is not based on just one specific feedstock or host organism. Data-driven and synthetic-biology approaches can be used to optimize both the host and pathways to maximize fuel production. Despite some success, challenges still need to be met to move advanced biofuels towards commercialization, and to compete with more conventional fuels.
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