Journal
NATURE
Volume 474, Issue 7351, Pages 318-326Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10212
Keywords
-
Categories
Funding
- Netherlands Organization for Scientific Research (NWO)
- Dutch Cancer Society [UVA2009-4416]
Ask authors/readers for more resources
The identification of intestinal stem cells as well as their malignant counterparts, colon cancer stem cells, has undergone rapid development in recent years. Under physiological conditions, intestinal homeostasis is a carefully balanced and efficient interplay between stem cells, their progeny and the microenvironment. These interactions regulate the astonishingly rapid renewal of the intestinal epithelial layer, which consequently puts us at serious risk of developing cancer. Here we highlight the microenvironment-derived signals that regulate stem-cell fate and epithelial differentiation. As our understanding of normal intestinal crypt homeostasis grows, these developments may point towards new insights into the origin of cancer and the maintenance and regulation of cancer stem cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available