Journal
NATURE
Volume 473, Issue 7348, Pages 470-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10108
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Funding
- NSF [CHE-0952753]
- NIH-NIGMS [GM088237]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0952753] Funding Source: National Science Foundation
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Recent advances in catalysis have made the incorporation of fluorine into complex organic molecules easier than ever before, but selective, general and practical fluorination reactions remain sought after. Fluorination of molecules often imparts desirable properties, such as metabolic and thermal stability, and fluorinated molecules are therefore frequently used as pharmaceuticals or materials. But the formation of carbon-fluorine bonds in complex molecules is a significant challenge. Here we discuss reactions to make organofluorides that have emerged within the past few years and which exemplify how to overcome some of the intricate challenges associated with fluorination.
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