Journal
NATURE
Volume 475, Issue 7356, Pages 333-341Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10318
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Funding
- Kavli Foundation
- National Institutes of Health [GM86217, GM84364, GM062427, RR022220, GM071329]
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The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclearpore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.
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