Journal
NATURE
Volume 468, Issue 7321, Pages 232-243Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature09613
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Funding
- Fondation Leducq
- European Research Council
- Wellcome Trust
- UK Medical Research Council
- Dunhill Medical Trust
- Biomedical Research Centres of the UK National Institute for Health Research
- European Commission
- Human Frontier Science Program
- Danish Medical Research Council
- Lundbeck Foundation
- Nordea Foundation Centre for Healthy Aging
- Novo Nordisk Foundation
- Canadian Institutes of Health Research
- Canada Research Chair in Neuroscience
- US National Institutes of Health (National Eye Institute)
- Medical Research Council [G0500495] Funding Source: researchfish
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Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
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