Journal
NATURE
Volume 465, Issue 7299, Pages 721-727Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature09230
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Funding
- Canadian Institutes of Health Research [199170, 186007]
- US National Institutes of Health [MH074127, MH088413, DP3DK085698, HG004535]
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Epigenetic modifications of DNA and histones might be crucial for understanding the molecular basis of complex phenotypes. One reason for this is that epigenetic factors are sometimes malleable and plastic enough to react to cues from the external and internal environments. Such induced epigenetic changes can be solidified and propagated during cell division, resulting in permanent maintenance of the acquired phenotype. In addition, the finding that there is partial epigenetic stability in somatic and germline cells allows insight into the molecular mechanisms of heritability. Epigenetics can provide a new framework for the search of aetiological factors in complex traits and diseases.
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