Journal
NATURE
Volume 468, Issue 7321, Pages 244-252Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature09614
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Funding
- German Research Foundation (Center for Molecular Physiology of the Brain in Gottingen) [SFB/TR43]
- European Leukodystrophy Association
- Myelin Project
- German Federal Ministry of Education and Research (Leukonet)
- European Union
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The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain. Cell biology and mouse genetics have provided insight into axon-glia signalling and the molecular architecture of the myelin sheath. Glial cells that myelinate axons were found to have a dual role by also supporting the long-term integrity of those axons. This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders.
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