Journal
NATURE
Volume 464, Issue 7288, Pages 529-535Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08983
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Funding
- National Institute on Aging of the US National Institutes of Health
- Ellison Medical Foundation
- Glenn Foundation for Medical Research
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During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest health threats of old age, with nearly 50% of adults over the age of 85 afflicted with Alzheimer's disease. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain ageing. Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline.
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