Journal
NATURE
Volume 458, Issue 7237, Pages 461-467Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07963
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Funding
- Max Planck Society
- Centre for Integrated Protein Science Munich
- Deutsche Krebshilfe
- RUBICON Network of Excellence
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With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.
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