Journal
NATURE
Volume 460, Issue 7257, Pages 831-838Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08301
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Funding
- Deutsche Forschungsgemeinschaft [SFB 593, TR1, GRK 1216]
- Max-Planck Gesellschaft
- von Behring-Rntgen-Stiftung
- German-Israeli Foundation for Scientific Research and Development
- Alexander von Humboldt-Stiftung
- Rhn Klinikum AG
- Fonds der Chemischen Industrie
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Iron-sulphur (Fe-S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the relative simplicity of Fe-S clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells. Different biogenesis machineries in both bacteria and eukaryotes have been discovered that assist Fe-S-protein maturation according to uniform biosynthetic principles. The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis.
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