Journal
NATURE
Volume 460, Issue 7257, Pages 848-854Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08303
Keywords
-
Categories
Funding
- US National Science Foundation Division of Chemistry [0719553]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0719553] Funding Source: National Science Foundation
Ask authors/readers for more resources
In nature, halogenation is a strategy used to increase the biological activity of secondary metabolites, compounds that are often effective as drugs. However, halides are not particularly reactive unless they are activated, typically by oxidation. The pace of discovery of new enzymes for halogenation is increasing, revealing new metalloenzymes, flavoenzymes, S-adenosyl-l-methionine (SAM)-dependent enzymes and others that catalyse halide oxidation using dioxygen, hydrogen peroxide and hydroperoxides, or that promote nucleophilic halide addition reactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available