Journal
NATURE
Volume 458, Issue 7237, Pages 453-460Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07962
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Funding
- German Research Foundation (DFG)
- Boehringer Ingelheim Fonds
- Helmholtz PhD fellowship
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As proteins travel through the endoplasmic reticulum (ER), a quality-control system retains newly synthesized polypeptides and supports their maturation. Only properly folded proteins are released to their designated destinations. Proteins that cannot mature are left to accumulate, impairing the function of the ER. To maintain homeostasis, the protein-quality-control system singles out aberrant polypeptides and delivers them to the cytosol, where they are destroyed by the proteasome. The importance of this pathway is evident from the growing list of pathologies associated with quality-control defects in the ER.
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