Journal
NATURE
Volume 458, Issue 7242, Pages 1127-1130Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07986
Keywords
-
Categories
Funding
- NIH
- American Lebanese and Syrian Associated Charities
- Ligue contre le Cancer
- INCa
- Canceropole
- ANR
- ANRS
- Active p53
- Apo-Sys EU networks
Ask authors/readers for more resources
The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available