Journal
NATURE
Volume 460, Issue 7255, Pages 587-591Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08197
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Funding
- NIH
- Ellison Medical Foundation
- Sidney Kimmel Cancer Research Foundation
- V Foundation
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The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.
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