Journal
NATURE
Volume 461, Issue 7266, Pages 900-907Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08536
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Funding
- US National Institutes of Health (NIH) [K99]
- National Institute of Neurological Disorders and Stroke
- National Institute of Mental Health
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Brain function emerges from the morphologies, spatial organization and patterns of connectivity established between diverse sets of neurons. Historically, the notion that neuronal structure predicts function stemmed from classic histological staining and neuronal tracing methods. Recent advances in molecular genetics and imaging technologies have begun to reveal previously unattainable details about patterns of functional circuit connectivity and the subcellular organization of synapses in the living brain. This sophisticated molecular and genetic 'toolbox', coupled with new methods in optical and electron microscopy, provides an expanding array of techniques for probing neural anatomy and function.
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