Journal
NATURE
Volume 462, Issue 7271, Pages 307-314Publisher
NATURE PORTFOLIO
DOI: 10.1038/nature08532
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Funding
- MRC Centre for Obesity and Related Metabolic Diseases
- Wellcome Trust
- NIHR Cambridge Biomedical Research Centre
- EU
- Medical Research Council [G9824984] Funding Source: researchfish
- MRC [G9824984] Funding Source: UKRI
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Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.
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