Journal
NATURE
Volume 460, Issue 7251, Pages 49-52Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08180
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Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
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