Journal
NATURE
Volume 454, Issue 7203, Pages 455-462Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07203
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL052173-12, P01 HL057346-11A18575, HL052173, P01 HL057346-100006, R01 HL052173, HL057346, P01 HL057346, R01 HL052173-11] Funding Source: Medline
- NIDDK NIH HHS [R01 DK042394, R37 DK042394-10, DK042394, R01 DK042394-09, R37 DK042394-11, R37 DK042394] Funding Source: Medline
Ask authors/readers for more resources
The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available