Journal
NATURE
Volume 451, Issue 7182, Pages 1069-1075Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature06639
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Funding
- NIA NIH HHS [R21 AG025355-02, R21 AG025355, R03 AG019834-02, R01 AG021904, R01 AG021904-06] Funding Source: Medline
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Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.
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