Journal
NATURE
Volume 454, Issue 7203, Pages 470-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07202
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCRR NIH HHS [RR021975] Funding Source: Medline
- NHLBI NIH HHS [HL30568, HL66088] Funding Source: Medline
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The nuclear receptors known as PPARs and LXRs are lipid-activated transcription factors that have emerged as key regulators of lipid metabolism and inflammation. PPARs and LXRs are activated by non-esterified fatty acids and cholesterol metabolites, respectively, and both exert positive and negative control over the expression of a range of metabolic and inflammatory genes. The ability of these nuclear receptors to integrate metabolic and inflammatory signalling makes them attractive targets for intervention in human metabolic diseases, such as atherosclerosis and type 2 diabetes, as well as for the modulation of inflammation and immune responses.
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