Journal
NATURE
Volume 451, Issue 7177, Pages 417-424Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature06485
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Funding
- NIDA NIH HHS [R01 DA006301-13, R01 DA015225-05, R01 DA015225] Funding Source: Medline
- NIGMS NIH HHS [R01 GM080337, R01 GM080337-04] Funding Source: Medline
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Novel reactions that can selectively functionalize carbon - hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon - hydrogen functionalization' method involves the insertion of metal carbenes and nitrenes into C - H bonds. This area has experienced considerable growth in the past decade, particularly in the area of enantioselective intermolecular reactions. Here we discuss several facets of these kinds of C - H functionalization reactions and provide a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents.
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