Journal
NATURE
Volume 454, Issue 7203, Pages 463-469Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07206
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Funding
- NIDDK NIH HHS [R01 DK054477-09A1, R01 DK054477] Funding Source: Medline
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Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1 alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
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