Journal
NATURE
Volume 455, Issue 7215, Pages 919-923Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07458
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Funding
- The Centre for Applied Genomics
- Genome Canada-Ontario Genomics Institute
- Canadian Institutes for Health Research
- Canadian Institute for Advanced Research
- McLaughlin Centre for Molecular Medicine
- Canadian Foundation for Innovation
- Ontario Ministry of Research Innovation
- National Institutes of Health [HD055751]
- Children's Brain Research Foundation
- Jean Young and Walden W. Shaw Foundation
- Autism Speaks
- SickKids Foundation
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Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy- number variation - a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged - in the human population. Genes affected by copy- number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy- number variants and the genes that they affect needs to be considered in an integrated context.
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