Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 9, Pages 616-621Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.887074
Keywords
cyclopeptide; co-culture; antifungal activity; mangrove fungi
Categories
Funding
- National Natural Science Foundation of China [21102049]
- Natural Science Foundation of Guangdong Province [9451064201003751]
- Science and Technology Project of Guangzhou City [11C12100771]
- Key Academic Program of the 3rd Phase '211 Project' of South China Agricultural University [2009B010100001]
- national scholarship fund of China for studying abroad [201208440268]
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A new cyclic tetrapeptide, cyclo-(l-leucyl-trans-4-hydroxy-l-prolyl-d-leucyl-trans-4-hydroxy-l-proline) (1), was isolated from the co-culture broth of two mangrove fungi Phomopsis sp. K38 and Alternaria sp. E33. The structure of 1 was determined by analysis of spectroscopic data and Marfey's analytic method. Primary bioassay demonstrated that compound 1 exhibited moderate to high inhibitory activity against four crop-threatening fungi including Gaeumannomyces graminis, Rhizoctonia cerealis, Helminthosporium sativum and Fusarium graminearum as compared with triadimefon.
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