Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 12, Pages 914-916Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.889133
Keywords
Centipeda minima L; isobutyroylplenolin; arnicolide D; cytotoxic; reactive oxygen species; nuclear factor-B
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Funding
- Grants-in-Aid for Scientific Research [25242013] Funding Source: KAKEN
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In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin. Treatment with isobutyroylplenolin and arnicolide D increased the levels of intracellular reactive oxygen species and decreased the levels of nuclear factor-B protein, resulting in cell cycle arrest in G1 phase and apoptosis. We also discuss the difference in structure and activity between these two compounds.
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