Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 7, Pages 431-437Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.871546
Keywords
Streptomyces sp neau-D50; hybrid isoprenoid; prenylated flavonoid; prenylated indole
Categories
Funding
- National Key Project for Basic Research [2010CB126102]
- National Natural Science Foundation of China [31000884, 30771427]
- Natural Science Foundation of Heilongjiang Province, China [C201029]
- Special Foundation for Scientific and Technological Innovation Research of Harbin [2011RFXXN038]
- Fund for Fostering Talents in Basic Science of the National Natural Science Foundation of China [J1210069]
- Northeast Agricultural University [2012RCB05]
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A new prenylated indole derivative 3-acetonylidene-7-prenylindolin-2-one (1) was isolated from the endophytic actinobacterium Streptomyces sp. neau-D50, together with four known hybrid isoprenoids, 7-isoprenylindole-3-carboxylic acid (2), 3-cyanomethyl-6-prenylindole (3), 6-isoprenylindole-3-carboxylic acid (4) and 7,4 '-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone (5). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis and comparison with data from the literature. Compounds 1 and 2 demonstrated strong cytotoxic activities against human lung adenocarcinoma cell line A549 with an IC50 of 3.3 and 5.1 mu gmL(-1), respectively, which are comparable to that of the positive control doxorubicin (4.2 mu gmL(-1)). Furthermore, compounds 1-4 exhibited potent antifungal activity against phytopathogenic fungi Colletotrichum orbiculare, Phytophthora capsici, Corynespora cassiicola and Fusarium oxysporum.
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