Journal
NATURAL PRODUCT RESEARCH
Volume 29, Issue 9, Pages 820-826Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.988620
Keywords
citromycetin analogue; fungi; spectroscopy; deep sea sediment
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Funding
- National Key Basic Research Program of China (973 Project) [2011CB915503]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- National Natural Science Foundation of China [52102308, 31270402, 20902094, 41176148, 21002110]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11030403]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001]
- Guangzhou scientific research project [2014J4100212]
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A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-(-)-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the fungal strain Ascomycota sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean. The structures of the compounds were established by spectroscopic data including 1D and 2D NMR and HR-ESI-MS. Compounds (1-9) were evaluated for antibacterial activity.
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