Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 23, Pages 2134-2139Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.926350
Keywords
Verrucosispora; proximicin A; antitumour activity
Categories
Funding
- Fujian Key Project [2012Y0077]
- National Significant Science and Technology Major Project for novel medicinal research [2012ZX09301002-003]
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Strain FIM06054 was isolated from a marine sponge sample collected from the East China Sea and was characterised as a strain of Verrucosispora genus on the basis of its 16S rRNA gene sequence. One new compound, FW054-1 (1), together with a known aminofuran compound proximicin A (2), was isolated from the culture broth of Verrucosispora sp. FIM06054. Their structures were elucidated on the basis of spectral analysis. 1 and 2 showed antiproliferative activity against several human tumour cell lines.
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