Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 16, Pages 1288-1292Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.898145
Keywords
Hericium erinaceum; mushroom; diketopiperazine alkaloids; antioxidant activity; antifungal activity
Categories
Funding
- earmarked fund for National Key Technology R&D Program of the Ministry of Science and Technology of China [2012BAD36B04]
- Program for New Century Excellent Talents in University [NCET-05-0852]
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Seven known compounds, three diketopiperazine alkaloids, 12 beta-hydroxyverruculogen TR-2 (1), fumitremorgin C (2) and methylthiogliotoxin (5), two hetero-spirocyclic gamma-lactam alkaloids, pseurotin A (3) and FD-838 (4), and cerevisterol (6) and herierin IV (7), were isolated from the mycelia of the basidiomycete Hericium erinaceum and identified by spectroscopic analyses. The antioxidant and antifungal activities of compounds 1-6 were evaluated. The results indicated that compounds 1, 3 and 6 exhibited potential antioxidant activity against DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical with their IC50 data of ca. 12 mu M, compared with positive control tertiary butylhydroquinone. In addition, compound 4 significantly inhibited the growth of two plant fungal pathogens Botrytis cinerea and Glomerella cingulata with an minimum inhibitory concentration of 6.25 mu M for each, similar to that of the positive fungicide, carbendazim. Compounds 1-5 were isolated from the genus Hericium for the first time.
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