Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 9, Pages 677-679Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.891113
Keywords
biotransformation; grandiflorenic acid; hydroxylation; 12 alpha-hydroxygrandiflorenic acid; Fusarium graminearum
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Funding
- Program for Excellent Young Teachers of Henan Province [2009GGJS-031]
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Biotransformation of grandiflorenic acid by permeabilised fungus Fusarium graminearum to yield its hydroxylation derivative, 12 alpha-hydroxygrandiflorenic acid, was studied. The biotransformed product was isolated by column chromatography and its structure was determined by mass spectrum and nuclear magnetic resonance analysis. Grandiflorenic acid was efficiently metabolised by the fungus. After 72h, the substrate was almost completely converted into the product.
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