Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 12, Pages 888-894Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.891112
Keywords
Dendrilla nigra; marine sponge; 3; 4-diarylpyrrole alkaloids; antitubercular
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Funding
- Ministry of Earth Sciences, New Delhi
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Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4g/mL) against Mycobacterium tuberculosis H37Rv.
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