Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 18, Pages 1507-1512Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.913242
Keywords
Cerbera odollam; theviridoside; theveside; semi-synthetic derivatives; cytotoxicity
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Funding
- Council of Scientific and Industrial Research (CSIR), India, under the 12th Five-Year Plan (FYP) project NAPAHA
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We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.
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