Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 15, Pages 1134-1141Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.915828
Keywords
Red Sea sponges; Dragmacidon coccinea; dragmacidoside; nucleosides; steroids; anti-inflammatory activity
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Chemical investigation of the Red Sea sponge Dragmacidon coccinea led to the isolation of a new nucleoside, dragmacidoside (1), along with eight known compounds: adenosine (2), inosine (3), deoxycytidine (4), methyl--d-glucopyranoside (5), clionasterol (6), stigmasterol (7), campesterol (8) and brassicasterol (9). The compounds were isolated from chloroform and ethyl acetate fractions of the methanolic extract of the sponge, and their structures were established based on various spectroscopic data including MS, 1D and 2D NMR (COSY, HSQC and HMBC). Biological testing revealed that the chloroform fraction possesses significant anti-inflammatory activity in the carrageenan-induced hind paw oedema in rats.
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