Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 14, Pages 1070-1074Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.905935
Keywords
Arthrinium sp; sponge; secondary metabolite; naphthalene glycoside
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Funding
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology [2013HS005]
- Open Foundation of the Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA [MBSMAT-2013-02]
- National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]
- Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
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One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O--l-rhamnopyranoside (1), together with one known -dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2M.
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