4.4 Article

Novel cyclopentenone derivatives produced by a rare actinobacterial strain Actinoalloteichus nanshanensis sp nov NEAU 119

Journal

NATURAL PRODUCT RESEARCH
Volume 27, Issue 20, Pages 1863-1869

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.771349

Keywords

Actinoalloteichus nanshanensis sp; nov; NEAU 119; cyclopentenone; cytotoxicity

Funding

  1. National Key Project for Basic Research [2010CB126102]
  2. National Natural Science Foundation of China [30771427, 31000884]

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Four novel cyclopentenone derivatives (1-4), characterising a cyclopentenone ring conjugated with a 1,8-dioxadecalin, were isolated from rare actinobacterial strain Actinoalloteichus nanshanensis sp. nov. NEAU 119. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. Bioassays indicated that compounds 1-4 showed low cytotoxicities against human leukaemia cell line K562 and human renal carcinoma cell line ACHN. To the best of our knowledge, this is the first example of isolation of C-11 cyclopentenones from actinomycetes.

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