New anti-inflammatory triterpene from the root of Ricinus communis

Liquid-liquid partitioning of Ricinus communis root methanol extract resulted in enrichment of compounds. Purification of the n-hexane fraction led to the isolation and characterisation of two triterpenes: one known compound lupeol (1) and a new diketone pentacyclic triterpene named as erandone (urs-6-ene-3,16-dione) (2), from the plant. Their structures were determined by various spectroscopic techniques. Crude methanolic, enriched n-hexane fraction and isolates at doses 100mg/kg p.o. exhibited significant (P<0.001) anti-inflammatory activity in carrageenan-induced hind paw oedema model.