Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 2, Pages 111-114Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.850687
Keywords
xylanthraquinone; fungus Xylaria sp; 2508; mPtPB
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Funding
- National Natural Science Foundation of China [20972197, 41276146, 21102020]
- 863 Foundation of China [2011AA09070201]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004, 2011A080403006]
- Fundamental Research Funds for the Central Universities of China [11lgjc01]
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Xylanthraquinone (1), a new anthraquinone, along with three known compounds, altersolanol A (2), deoxybostrycin (3) and bostrycin (4) was isolated from the fungus Xylaria sp. 2508 from the South China Sea. The structures of these compounds were identified by NMR experiments, and the absolute configuration of compound 1 was further confirmed by single-crystal X-ray diffraction with Cu K radiation. Compounds 1-4 did not show inhibitory activities against Mycobacterium tuberculosis protein tyrosine phosphatase B (IC50 values more than 100 mu M).
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