Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 4, Pages 239-244Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.843177
Keywords
Penicillium citrinum; polyketide; cathepsin B inhibitor
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Funding
- 973 Program of China [2010CB833803]
- 863 Program of China [2012AA092104]
- National Marine Public Welfare Research Project of China [201305017]
- National Natural Science Foundation of China [40931160435, 40976090]
- Science and Technology Foundation of Guangdong Province [2010B030600009]
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Three new polyketides penicitrinol G (1), penicitrinol H (2) and 2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone (3) together with one known cathepsin B inhibitor chrysophanol (4) were isolated from a culture broth of marine-derived fungus Penicillium citrinum SCSGAF 0167. Their structures were determined by spectroscopic methods. Compound 4 exhibited inhibitory activity against cathepsin B with IC50 value of 1.7 mu M.
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