Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 1, Pages 12-17Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.827194
Keywords
ascidian; Synoicum new species; rubrolide R; antiviral
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Funding
- Ministry of Earth Sciences (MoES), New Delhi
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A new furanone metabolite of the rubrolide family, rubrolide R as diacetate (1), was isolated from a new species of the ascidian Synoicum, besides the known compounds rubrolide A (as diacetate), cadiolide B and prunolide A. The structure of the new rubrolide was elucidated by a study of spectral data. The crude extract and isolated compounds (prunolide A and cadiolide B) showed antiviral activity against the Japanese encephalitis virus. Prunolide A showed cytotoxic activity against breast cancer cell lines at a concentration of <1 mu M.
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