Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 22, Pages 2126-2131Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.793686
Keywords
aminophenoxazinone; maroxazinone; actinomycete; spectroscopy; cytotoxic activity
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Chemical investigation of the marine Streptomyces sp. Eg25 led to the isolation of one new natural 2-aminophenoxazin-3-one-8-carboxylic acid methyl ester named maroxazinone (1) as well as the known compounds elloxazinone A (2), exfoliazone (3), carboxyexfoliazone (4), elloxazinone B (5) and venezueline D (6). The chemical structures of the isolated compounds were deduced from extensive studies of NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC and HMBC) and mass spectra. The cytotoxic activities of the new maroxazinone (1) and venezueline D (6) against breast carcinoma cell line (MCF7), liver carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) were investigated.
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