Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 12, Pages 1060-1066Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.708659
Keywords
Aspergillus terreus; Laurencia ceylanica; butyrolactone; 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2; 5-dihydro-2-furanone; -glucuronidase
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Funding
- Third World Academy of Science (TWAS), Trieste, Italy
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An endophytic fungus Aspergillus terreus, var. boedijnii (Blochwitz) was isolated from red marine alga Laurencia ceylanica, J. Agardh, cultured in large scale and extracted with EtOAc. The above-mentioned extract yielded a new butyrolactone, 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2,5-dihydro-2-furanone (1), along with the previously reported nine compounds, butyrolactone-1 (2), 6-hydroxymellin (3), (3R, 4R)-6,7-dimethoxy-4-hydroxymellin (4), (+)-territonin (5), (+)-territonin-A (6), (+)-asterrelenin (7), (+)-terrein (8), oleic acid (9) and glucopyranosyl--sitosterol (10), on column and preparative thin-layer chromatography. Compounds 1-8 were subjected to -glucuronidase inhibitory activity test, and 1 showed a remarkable activity, while 2 and 7 showed moderate activity.
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