Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 13, Pages 1197-1201Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.722084
Keywords
chloranthaceae; Sarcandra glabra; sesquiterpene; atractylenolide IV; cytotoxic activity
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Funding
- National Natural Science Foundation of China [20572132]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Administration of Traditional Chinese Medicine of P.R. China [2006LHR21]
- Major Scientific and Technological Special Project 'Significant New Drugs Creation' of China in the Eleventh Five-Year: The Large Technological Platform for Comprehensive Research and Development of New Drugs [2009ZX093012003]
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A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1-4 showed no remarkable cytotoxic activity against Hela, HCT-8 and MCF-7 cancer cell lines with IC50>50 mu gmL(-1).
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