Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 12, Pages 1132-1135Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.711328
Keywords
Fraxinus rhynchophylla; pancreatic lipase; secoiridoid; obesity
Categories
Funding
- Basic Science Research Program [2011-0003494]
- Medical Research Center program through the National Research Foundation of Korea [2010-0029480]
Ask authors/readers for more resources
Pancreatic lipase digests dietary fats by hydrolysis, which is a key enzyme for lipid absorption. Therefore, reduction of fat absorption by the inhibition of pancreatic lipase is suggested to be a therapeutic strategy for obesity. From the EtOAc-soluble fraction of the stem barks of Fraxinus rhynchophylla (Oleaceae), four secoiridoids such as ligstroside (1), oleuropein (2), 2-hydroxyoleuropein (3) and hydroxyframoside B (4) were isolated. The inhibitory activity of these compounds on pancreatic lipase was assessed using porcine pancreatic lipase as an invitro assay system. Compound 4 showed the strongest inhibition on pancreatic lipase, which followed by compounds 1-3. In addition, compound 4 exerted inhibitory effect on pancreatic lipase in a mixed mechanism of competitive and noncompetitive manner. Taken together, F. rhynchophylla and its constituents might be beneficial to obesity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available