Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 3, Pages 201-207Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.666746
Keywords
Dracocephalum moldavica; flavonoids; acacetin; menthane monoterpenoid
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Funding
- National Natural Science Foundation of China [30973622]
- Foundation for Excellent Young Scientists in Shandong Province [2008BS02015]
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A systematic phytochemical investigation of the aerial parts of Dracocephalum moldavica led to the isolation of 1 new and 16 known compounds. Based on spectroscopic analyses, the new compound was elucidated as a flavonoid glycoside, acacetin-7-O-(4?-acetyl)-glucopyranoside (1). The 16 known compounds were identified as: 9 flavonoids (210), 2 lignans (1112), 4 triterpeniods (1316) and 1 menthane-type monoterpenoid (17). All the 17 compounds were reported for the first time from D. moldavica. Compound 1 exhibited mild radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Although compound 17, named as citrylidene malonic acid, was a known compound, it possessed an uncommon tricyclic dilactone skeleton, the structure was secured by X-ray crystallography. In addition, compound 17 was tested for cytotoxic activity against A549 cell line, only weak cytotoxicity was shown.
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