Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 17, Pages 1528-1531Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.730043
Keywords
lichen secondary metabolites; methicillin-resistant staphylococci; antimicrobial resistance; antibacterial activity
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Funding
- MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca) EX MURST
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The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.
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