Journal
NATURAL PRODUCT RESEARCH
Volume 28, Issue 4, Pages 213-220Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.751596
Keywords
sulphated triterpene glycosides; cytotoxic; antiproliferative; Pseudocnus dubiosus leoninus
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Funding
- University of Buenos Aires
- National Research Council of Argentina (CONICET)
- ANPCyT/FONCYT [PICT 34111]
- CONICET
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A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (H-1 and C-13 NMR, H-1,H-1-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.
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