Journal
NATURAL PRODUCT RESEARCH
Volume 26, Issue 5, Pages 387-392Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2010.487188
Keywords
acetylcholinesterase inhibitor; Nelumbo nucifera; aporphine alkaloid; Alzheimer's disease; structure-activity correlations
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Funding
- National Natural Science Foundation of China [20802031]
- Lanzhou University of Technology [Q200904]
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N-methylasimilobine (1), a new-found strong acetylcholinesterase (AChE) inhibitor, along with two weakly active aporphine alkaloids, nuciferine (2) and nornuciferine (3) were separated from Nelumbo nucifera. N-methylasimilobine (1) inhibited 50% of AChE activity at the concentrations of 1.5 +/- 0.2 mu g mL(-1) when the standard IC50 value of Physostigmine was 0.013 +/- 0.002 mu g mL(-1). The mode of AChE inhibition by 1 was reversible and non-competitive. In addition, molecular modelling was performed to explore the binding mode of inhibitor 1 at the active site of AChE.
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